Nancy L Heard-Costa, PhD
Assistant Professor
Boston University Chobanian & Avedisian School of Medicine
Neurology

PhD, University of Alabama at Birmingham
MPH, Boston University School of Public Health
BA, Ripon College



Expertise includes: Data management - both phenotype and genetic in nature, including storage , maintenance, quality control; Genetic data cleaning - both in unrelated and related individuals; Pedigree creation, verification and maintenance; Forensic analysis of genetic samples - identification of incorrect, cryptic duplicate, and related subject; Statistical analysis -from univariate to multivariate and more complex models, including design, implementation and interpretation/conclusion; Genetic statistical analysis - linkage, association and meta-analysis, including design, implementation and interpretation/conclusion; and Human Medical Genetics theory and practice.

Center Faculty Member
Framingham Heart Study
Framingham Heart Study




Return of Genomic Results and Estimating Penetrance in Population-Based Cohorts
08/01/2019 - 06/30/2024 (Subcontract PI)
Broad Institute, Inc., The NIH NHLBI
1R01HL143295-04



Title


Yr Title Project-Sub Proj Pubs

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Kirmani S, Huan T, Van Amburg JC, Joehanes R, Uddin MM, Nguyen NQH, Yu B, Brody JA, Fornage M, Bressler J, Sotoodehnia N, Ong DA, Puddu F, Floyd JS, Ballantyne CM, Psaty BM, Raffield LM, Natarajan P, Conneely KN, Weinstock JS, Carson AP, Lange LA, Ferrier K, Heard-Costa NL, Murabito J, Bick AG, Levy D. Epigenome-wide DNA methylation association study of CHIP provides insight into perturbed gene regulation. Nat Commun. 2025 May 20; 16(1):4678.View Related Profiles. PMID: 40393957; PMCID: PMC12092741; DOI: 10.1038/s41467-025-59333-w;
     
  2. Meena D, Huang J, Zare M, Hasbani NR, Romuald BP, Mustafa R, van der Laan SW, Xu H, Terry JG, Bis JC, Jain D, Palmer ND, Heard-Costa N, Min YI, Guo X, Yao J, Taylor KD, Tan J, Peralta J, Pereira AC, Khan A, Choudhury A, Newman AB, Xiang AH, Hingorani A, Freedman BI, O'Donnell CJ, Giambartolomei C, Herrington DM, Jacobs DR, Klarin D, Wang FF, Heiss G, Doddapaneni H, Hodis HN, Broome J, Wilson JG, Brandenburg JT, Blangero J, Krieger JE, Smith JD, Viaud-Martinez KA, Ryan KA, Lange LA, Montasser ME, Mahaney MC, Mokry M, Fornage M, Munroe P, Gibbs RA, Tracy RP, Kim RW, Damrauer SM, Rich SS, Hsueh WA, Chen YI, Morrison AC, Mitchell BD, Carr JJ, Psaty BM, Bowden DW, Vasan RS, Correa A, Post WS, Goodarzi MO, Raffel LJ, Curran JE, Ramsay M, Rotter JI, Elliott P, Franceschini N, de Vries PS, Tzoulaki I, Dehghan A. Genome-wide association study and multi-ancestry meta-analysis identify common variants associated with carotid artery intima-media thickness. medRxiv. 2025 Apr 14.View Related Profiles. PMID: 40321265; PMCID: PMC12047956; DOI: 10.1101/2025.04.11.25325582;
     
  3. Zhang X, Brody JA, Graff M, Highland HM, Chami N, Xu H, Wang Z, Ferrier KR, Chittoor G, Josyula NS, Meyer M, Gupta S, Li X, Li Z, Allison MA, Becker DM, Bielak LF, Bis JC, Boorgula MP, Bowden DW, Broome JG, Buth EJ, Carlson CS, Chang KM, Chavan S, Chiu YF, Chuang LM, Conomos MP, DeMeo DL, Du M, Duggirala R, Eng C, Fohner AE, Freedman BI, Garrett ME, Guo X, Haiman C, Heavner BD, Hidalgo B, Hixson JE, Ho YL, Hobbs BD, Hu D, Hui Q, Hwu CM, Jackson RD, Jain D, Kalyani RR, Kardia SLR, Kelly TN, Lange EM, LeNoir M, Li C, Le Marchand L, McDonald MN, McHugh CP, Morrison AC, Naseri T, O'Connell J, O'Donnell CJ, Palmer ND, Pankow JS, Perry JA, Peters U, Preuss MH, Rao DC, Regan EA, Reupena SM, Roden DM, Rodriguez-Santana J, Sitlani CM, Smith JA, Tiwari HK, Vasan RS, Wang Z, Weeks DE, Wessel J, Wiggins KL, Wilkens LR, Wilson PWF, Yanek LR, Yoneda ZT, Zhao W, Zöllner S, Arnett DK, Ashley-Koch AE, Barnes KC, Blangero J, Boerwinkle E, Burchard EG, Carson AP, Chasman DI, Ida Chen YD, Curran JE, Fornage M, Gordeuk VR, He J, Heckbert SR, Hou L, Irvin MR, Kooperberg C, Minster RL, Mitchell BD, Nouraie M, Psaty BM, Raffield LM, Reiner AP, Rich SS, Rotter JI, Benjamin Shoemaker M, Smith NL, Taylor KD, Telen MJ, Weiss ST, Zhang Y, Heard-Costa N, Sun YV, Lin X, Cupples LA, Lange LA, Liu CT, Loos RJF, North KE, Justice AE. Whole genome sequencing analysis of body mass index identifies novel African ancestry-specific risk allele. Nat Commun. 2025 Apr 11; 16(1):3470.View Related Profiles. PMID: 40216759; PMCID: PMC11992084; DOI: 10.1038/s41467-025-58420-2;
     
  4. Georgakis MK, Malik R, Bounkari OE, Hasbani NR, Li J, Huffman JE, Shakt G, Tack RWP, Kimball TN, Asare Y, Morrison AC, Tsao NL, Judy R, Mitchell BD, Xu H, Montasser ME, Do R, Kenny EE, Loos RJF, Terry JG, Carr JJ, Bis JC, Psaty BM, Longstreth WT, Young KA, Lutz SM, Cho MH, Broome J, Khan AT, Wang FF, Heard-Costa N, Seshadri S, Vasan RS, Palmer ND, Freedman BI, Bowden DW, Yanek LR, Kral BG, Becker LC, Peyser PA, Bielak LF, Ammous F, Carson AP, Hall ME, Raffield LM, Rich SS, Post WS, Tracy RP, Taylor KD, Guo X, Mahaney MC, Curran JE, Blangero J, Clarke SL, Haessler JW, Hu Y, Assimes TL, Kooperberg C, Bernhagen J, Anderson CD, Damrauer SM, Zand R, Rotter JI, de Vries PS, Dichgans M. Rare damaging CCR2 variants are associated with lower lifetime cardiovascular risk. Genome Med. 2025 Mar 21; 17(1):27.View Related Profiles. PMID: 40119478; PMCID: PMC11929344; DOI: 10.1186/s13073-025-01456-2;
     
  5. Wang D, Scalici A, Wang Y, Lin H, Pitsillides A, Heard-Costa N, Cruchaga C, Ziegemeier E, Bis JC, Fornage M, Boerwinkle E, De Jager PL, Wijsman E, Dupuis J, Renton AE, Seshadri S, Goate AM, DeStefano AL, Peloso GM. Frequency of variants in Mendelian Alzheimer's disease genes within the Alzheimer's Disease Sequencing Project. J Alzheimers Dis. 2025 Apr; 104(3):841-851.View Related Profiles. PMID: 40084664; DOI: 10.1177/13872877251320375;
     
  6. Orchard P, Blackwell TW, Kachuri L, Castaldi PJ, Cho MH, Christenson SA, Durda P, Gabriel S, Hersh CP, Huntsman S, Hwang S, Joehanes R, Johnson M, Li X, Lin H, Liu CT, Liu Y, Mak ACY, Manichaikul AW, Paik D, Saferali A, Smith JD, Taylor KD, Tracy RP, Wang J, Wang M, Weinstock JS, Weiss J, Wheeler HE, Zhou Y, Zoellner S, Wu JC, Mestroni L, Graw S, Taylor MRG, Ortega VE, Johnson CW, Gan W, Abecasis G, Nickerson DA, Gupta N, Ardlie K, Woodruff PG, Zheng Y, Bowler RP, Meyers DA, Reiner A, Kooperberg C, Ziv E, Ramachandran VS, Larson MG, Cupples LA, Burchard EG, Silverman EK, Rich SS, Heard-Costa N, Tang H, Rotter JI, Smith AV, Levy D, Aguet F, Scott L, Raffield LM, Parker SCJ. Cross-cohort analysis of expression and splicing quantitative trait loci in TOPMed. medRxiv. 2025 Feb 21.View Related Profiles. PMID: 40034763; PMCID: PMC11875316; DOI: 10.1101/2025.02.19.25322561;
     
  7. Li X, Chen H, Selvaraj MS, Van Buren E, Zhou H, Wang Y, Sun R, McCaw ZR, Yu Z, Jiang MZ, DiCorpo D, Gaynor SM, Dey R, Arnett DK, Benjamin EJ, Bis JC, Blangero J, Boerwinkle E, Bowden DW, Brody JA, Cade BE, Carson AP, Carlson JC, Chami N, Chen YI, Curran JE, de Vries PS, Fornage M, Franceschini N, Freedman BI, Gu C, Heard-Costa NL, He J, Hou L, Hung YJ, Irvin MR, Kaplan RC, Kardia SLR, Kelly TN, Konigsberg I, Kooperberg C, Kral BG, Li C, Li Y, Lin H, Liu CT, Loos RJF, Mahaney MC, Martin LW, Mathias RA, Mitchell BD, Montasser ME, Morrison AC, Naseri T, North KE, Palmer ND, Peyser PA, Psaty BM, Redline S, Reiner AP, Rich SS, Sitlani CM, Smith JA, Taylor KD, Tiwari HK, Vasan RS, Viali S, Wang Z, Wessel J, Yanek LR, Yu B, Dupuis J, Meigs JB, Auer PL, Raffield LM, Manning AK, Rice KM, Rotter JI, Peloso GM, Natarajan P, Li Z, Liu Z, Lin X. A statistical framework for multi-trait rare variant analysis in large-scale whole-genome sequencing studies. Nat Comput Sci. 2025 Feb; 5(2):125-143.View Related Profiles. PMID: 39920506; PMCID: PMC11981678; DOI: 10.1038/s43588-024-00764-8;
     
  8. Jakubek YA, Ma X, Stilp AM, Yu F, Bacon J, Wong JW, Aguet F, Ardlie K, Arnett DK, Barnes K, Bis JC, Blackwell T, Becker LC, Boerwinkle E, Bowler RP, Budoff MJ, Carson AP, Chen J, Cho MH, Coresh J, Cox NJ, de Vries PS, DeMeo DL, Fardo DW, Fornage M, Guo X, Hall ME, Heard-Costa N, Hidalgo B, Irvin MR, Johnson AD, Jorgenson E, Kenny EE, Kessler MD, Levy D, Li Y, Lima JAC, Liu Y, Locke AE, Loos RJF, Machiela MJ, Mathias RA, Mitchell BD, Murabito JM, Mychaleckyj JC, North KE, Orchard P, Parker SCJ, Pershad Y, Peyser PA, Pratte KA, Psaty BM, Raffield LM, Redline S, Rich SS, Rotter JI, Shah SJ, Smith JA, Smith AP, Smith A, Taub MA, Tiwari HK, Tracy R, Tuftin B, Bick AG, Sankaran VG, Reiner AP, Scheet P, Auer PL. Genomic and phenotypic correlates of mosaic loss of chromosome Y in blood. Am J Hum Genet. 2025 Feb 06; 112(2):276-290.View Related Profiles. PMID: 39809269; PMCID: PMC11866972; DOI: 10.1016/j.ajhg.2024.12.014;
     
  9. Magavern EF, Deshmukh H, Asselin G, Theusch E, Trompet S, Li X, Noordam R, Chen YI, Seeman TE, Taylor KD, Post WS, Tardif JC, Paul DS, Benjamin EJ, Heard-Costa NL, Vasan RS, Rotter JI, Krauss RM, Jukema JW, Ridker PM, Munroe PB, Caulfield MJ, Chasman DI, Dubé MP, Hitman GA, Warren HR. GWAS of CRP response to statins further supports the role of APOE in statin response: A GIST consortium study. Pharmacol Res. 2025 Feb; 212:107575.View Related Profiles. PMID: 39798939
     
  10. Liu C, Joehanes R, Ma J, Xie J, Yang J, Wang M, Huan T, Hwang SJ, Wen J, Sun Q, Cumhur DY, Heard-Costa NL, Orchard P, Carson AP, Raffield LM, Reiner A, Li Y, O'Connor G, Murabito JM, Munson P, Levy D. Integrating Whole Genome and Transcriptome Sequencing to Characterize the Genetic Architecture of Isoform Variation and its Implications for Health and Disease. medRxiv. 2024 Dec 06.View Related Profiles. PMID: 39677465; PMCID: PMC11643148; DOI: 10.1101/2024.12.04.24318434;
     
Showing 10 of 121 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 121 publications over 24 distinct years, with a maximum of 17 publications in 2023

YearPublications
20013
20021
20036
20042
20052
20061
20074
20093
20103
20111
20123
20134
20145
20155
20164
20176
20184
20195
20202
20219
202211
202317
202411
20259

In addition to these self-described keywords below, a list of MeSH based concepts is available here.

genetic analysis
genetic forensic analysis
pedigree analysis
statistical analysis
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72 E. Concord St Robinson (B)
Boston MA 02118
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